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    • The Evidence for MLS® Laser Therapy:

      Wound Healing

    •  

      Last updated: August 2026

      MLS® laser therapy nearly halved healing time in severe burn injuries — complete epithelialization in a median of 40 days versus 73 days with standard care alone (p<0.001) — in a comparative study of 65 patients (Postoiu et al., 2026).

      Across four published studies covering severe burns, diabetic foot ulcers, and non-healing venous leg ulcers, MLS® has shown consistent effects on wound closure speed, pain, and the underlying cellular repair process, spanning one comparative clinical study, two published case reports, and one cellular mechanism study.

    • Quick summary

      Condition Design n Key result
      Severe burn injuries Comparative study 65 Epithelialization: 40 days vs. 73 days (p<0.001)
      Non-healing venous leg ulcer Case report 1 Ulcer >50% smaller by session 5; fully closed by session 10
      Diabetic foot ulcer Case report 1 Complete closure after 20 sessions; healed through 2-month follow-up
      Fibroblast activity / inflammation control In vitro cellular study — Reversed cytokine-driven inflammation; restored normal fibroblast function
      How to read this evidence

      The studies below are grouped by design, from strongest (a controlled comparative study) to supporting (individual case reports and cellular research). A comparative study with a control group gives a more reliable estimate of effect than a single case; case reports demonstrate real-world outcomes in individual patients but can’t rule out other explanations for improvement. We’ve labelled each accordingly.

    • Does MLS® laser speed up burn healing?

      Comparative clinical study

      Severe burn injuries. In a comparative study of 65 patients with severe burn injuries, 35 patients prospectively treated with adjunctive MLS® laser therapy plus standard care were compared against 30 retrospectively identified patients who received standard care alone, followed for up to 20 days. Patients treated with MLS® achieved complete epithelialization significantly faster (median 40 days vs. 73 days, p<0.001) and had significantly greater wound area reduction (median 434 cm² vs. 137 cm², p=0.0012). These effects held even after statistically adjusting for burn extent, burn depth, age, and diabetes. The MLS® group also showed significant improvements in pain, pruritus (itch), scar quality, and functional recovery (all p<0.001).

      Source: Postoiu RL, Popescu C, Marinescu S, Onose G. “Advancements with Photobiomodulation in Post-Burn Management/Rehabilitation: A Comparative Study on Multiwave Locked System (MLS) LASER Therapy Outcomes.” Life (Basel). 2026;16(4):611. DOI: 10.3390/life16040611 · PMID: 42073421 Read the article

    • Can MLS® laser heal chronic wounds that haven’t responded to standard care?

      Case reports

      Non-healing venous leg ulcer. A 69-year-old woman with a chronic venous leg ulcer that had failed 9 months of standard wound care — including hospitalization for a Pseudomonas aeruginosa infection, IV antibiotics, and compression therapy — was in severe enough pain to require regular opioid medication before starting MLS® laser therapy. She received 10 MLS® sessions (MPhi 5 device) over 48 days, alongside continued standard debridement and dressing. She reported a significant reduction in pain and stopped taking opioids after her very first laser session. The ulcer had shrunk by more than 50% by the fifth session and was fully closed by the tenth, with no adverse effects.

      Source: Pellizzon J. “MLS® Laser Therapy for the Management of a Non-Healing Venous Leg Ulcer: A Case Report.” Energy for Health, 2024;[24]. Read the case report (PDF)

      Diabetic foot ulcer. A 65-year-old woman with type 2 diabetes and peripheral neuropathy had a diabetic foot ulcer that had progressively worsened over 7 months despite dressing and repeated courses of antibiotics for infection, with no granulation tissue present. Treated with 20 sessions of MLS®-MiS laser therapy (4 sessions per week) alongside her existing wound care, the ulcer showed gradual reduction in size and inflammation over the course of treatment and reached complete closure by the end of the 20-session course. At 1- and 2-month follow-up, the skin remained fully healed with no recurrence and no side effects.

      Source: Viliani T, Lombardi B. “Healing of Leg Diabetic Ulcer Treated with MLS®-MiS Laser (MiS – MLS® High Peak Pulse): A Case Report.” Energy for Health, [21]:9-11. DOI: 10.1155/2014/626127 · Read the case report (PDF)

    • What’s the cellular mechanism behind MLS® laser’s effect on wound healing?

      Cellular mechanism evidence

      Fibroblast activity and inflammation control. In an in vitro study of human dermal fibroblasts exposed to inflammatory cytokines (IL-1β and TNF-α) to simulate a wound-healing environment, treatment with MLS-MiS near-infrared laser therapy reversed cytokine-driven increases in inflammatory pathways (iNOS, COX-2/PGE2) and restored normal fibroblast structure and function, including reorganizing the cytoskeleton and normalizing collagen I and MMP-1 levels — cellular changes that directly support controlled, non-fibrotic wound repair rather than scarring.

      Source: Genah S, Cialdai F, Ciccone V, Sereni E, Morbidelli L, Monici M. “Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing.” Biomedicines. 2021;9(3):307. DOI: 10.3390/biomedicines9030307 · PMID: 33809724. Read the study.

    • This page summarises independently published research on MLS® laser therapy for wound healing. It is provided for clinical and educational reference and does not replace individualised clinical judgment. Heal with Laser is the exclusive distributor of ASA Laser MLS® technology in Australia and New Zealand